"It's unbelievable," Bills quarterback Ryan Fitzpatrick said. "I mean, for there not to be a batted pass at the line or a fluke ... Whatever it is, that's unbelievable.
"It's mind boggling to have a statistic like that and to go that long without throwing an interception."
Brady has thrown only four interceptions this year, the last two coming Oct. 17 against the Baltimore Ravens.
He has thrown at least two touchdown passes and no interceptions in seven straight games, an NFL record. Odds suggest he will extend his streak Sunday. The Bills have recorded just 10 interceptions this year, tied for 27th in the league.
The Patriots lead the NFL with a plus-20 turnover margin.
"If you look at their team one thing that you can point to is that they don't turn the ball over," Fitzpatrick said. "It is amazing how well they've taken care of the ball this year, and that's something that you learn from, too. You learn from a team like this that's so successful, and one of the reasons being that they don't give the ball away."