Wide receiver Marquise Goodwin -- Goodwin tweaked his hamstring late in practice last week and did not play in the preseason opener in Canton, Ohio. He returned to practice Tuesday but didn't appear to be full-go. The Bills could hold him out another game.
Tight end Tony Moeaki -- After missing Sunday's game, Moeaki was back in uniform Tuesday but didn't take part in team drills. The case was the same Wednesday. It's unlikely he'll play Friday.
Center Doug Legursky -- Legursky played in Sunday's game but was a surprise absence from practice Tuesday with a back injury. He was at the team's walk-through Wednesday, so the injury doesn't appear to be serious, but he's unlikely to play Friday.
Tackle Edawn Coughman -- The backup lineman left Tuesday's practice with an oblique injury and didn't practice Wednesday.
Defensive tackle Marcell Dareus -- Dareus didn't finish Wednesday's practice because of a hamstring injury. It didn't appear to be serious, but the Bills could take the extra precaution with their Pro Bowler and hold him out Friday.
Cornerback Leodis McKelvin -- McKelvin was in a baseball cap for Tuesday and Wednesday's practice, which is a step back from his level of participation earlier in camp. The Bills say it's not a setback, but don't expect McKelvin to play Friday.
Cornerback Stephon Gilmore -- The Bills have been easing Gilmore back from hip surgery and it wouldn't be surprising if he was held out again Friday.
Safety Da'Norris Searcy -- Searcy has a family situation but told coach Doug Marrone he wants to play Friday.
Safety Jonathan Meeks -- The second-year safety suffered a neck injury in Wednesday's practice, putting his status for Friday's game in doubt.
Safety Derek Brim -- The rookie was held out of Tuesday's practice with a hip injury and returned on a limited basis Wednesday. His status for Friday is uncertain.
Safety Kenny Ladler -- Like Brim, the rookie was seen on the sideline during Wednesday's practice riding an exercise bike during team drills, putting his status for the game in doubt.