All eyes will be on Ben Roethlisberger and the Steelers to see how they respond to their Week 1 loss against Baltimore.
Early gut check for Steelers: Everyone wants to see how Pittsburgh responds after taking its worst beating ever from Baltimore. The Steelers said all week that there is no panic in the locker room, and you tend to believe them because they return 21 of 22 starters from a team that played in the Super Bowl. But the heat will be turned up if the Steelers fail to put away the rebuilding Seahawks and go through the motions in their home opener. The critics say Pittsburgh looked slow and old against the Ravens. This is Pittsburgh's chance to respond.
Ravens' biggest concern: An emotional hangover from last Sunday would spell trouble for the Ravens against Chris Johnson, who is a threat to score on any play. After getting nine carries last game, the Titans running back thinks he could get as many as 25 touches Sunday, which would present a challenge for the Ravens. Three years ago against the Ravens, Johnson had 100 yards from scrimmage before leaving with an ankle injury. Baltimore's linebackers are tough and physical but lack great speed. Tracking Johnson sideline to sideline is a huge task.
Avoid slow start: Every team wants to start fast. But it's essential for the Browns and Colt McCoy. Playing catchup with the Colts means defensive ends Dwight Freeney and Robert Mathis begin to tee off. The big worry is Mathis, even though he's been limited in practice this week with a neck injury. With Tony Pashos out with an ankle injury, Cleveland will rotate Artis Hicks and Oniel Cousins at right tackle, where they'll line up against Mathis. That's the biggest mismatch of the game.
Give the ball to Benson: Bengals running back Cedric Benson is looking for 100-yard rushing games in consecutive weeks for the first time since the end of the 2008 season. That should be a primary goal for Cincinnati against a banged-up Broncos defense. Denver could be without two starters (defensive end Elvis Dumervil and weakside linebacker D.J. Williams) along with a couple of backups (defensive tackle Marcus Thomas and nose tackle Ty Warren). It seems like a no-brainer to commit to a ground-and-pound game against the Broncos, who allowed 190 yards rushing against Oakland on Monday.
Steelers' target: The bull's-eye is squarely on Seattle quarterback Tarvaris Jackson. The Steelers should be revved up after managing one sack in the season opener and now facing a ragged Seattle offensive line. The Seahawks' blocking is so shaky that even a mobile quarterback like Jackson got sacked five times Sunday. It should be big days for James Harrison and LaMarr Woodley.