What it means: The Browns lost for the third time in four games, securing their spot in last place in the AFC North. Cleveland (3-4) is the only team in the division with a losing record, falling 2.5 games behind the Steelers. It's the third time the Browns have lost by double digits.
Thumbs down: Middle linebacker D'Qwell Jackson. The offense should get a "Thumbs down" for three quarters, but Jackson made the critical error of the game. With the Browns trailing by seven points with under four minutes to go, Jackson stopped Frank Gore on third-and-3. But he grabbed Gore's facemask, which allowed the 49ers to convert the first down and eventually kick the game-clinching field goal.
McCoy watch: Colt McCoy was sacked four times, fumbled once (which set up a 49ers touchdown) and was intercepted when he threw into double coverage. He finished 22-of-34 for 241 yards.
Running on empty: Starting running back Peyton Hillis missed his second straight game with a hamstring injury, and backup Montario Hardesty left with a calf injury in the first half. As a result, the Browns didn't break a run longer than 9 yards.
What's next: The Browns play at the Houston Texans, which wraps up a stretch of three road games in four weeks.