What it means: The Colts were without their league-leading tackler -- safety LaRon Landry -- and their leading tackler -- linebacker Pat Angerer -- from two seasons ago while having to face a San Francisco offense trying to get back on track. The Colts stood up to the challenge outside of a rough series on which 49ers running back Frank Gore ran wild. The Colts locked up 49ers quarterback Colin Kaepernick and their offense the rest of the game. The Colts held the 49ers to 254 total yards and forced two turnovers. Kaepernick was only 13-of-27 for 150 yards, and Gore gained only 12 yards in the second half after rushing for 70 in the first.
Stock watch: Something had to give between Colts quarterback Andrew Luck and his former college coach Jim Harbaugh. Luck was 5-0 after losses, and Harbaugh was 7-0 in the same situation. Luck got the better of Harbaugh to keep his perfect record intact. Luck sealed the game for the Colts when he ran in untouched from 6 yards out to put the Colts up 20-7 with 4:27 left in the game.
Premature flags: The officials had an issue with getting ahead of themselves during the first half. Referee Terry McAulay had to clarify that they threw an inadvertent flag three times. The officials cleaned it up in the second half, with no miscues during the final 30 minutes.
What’s next: The Colts stay on the road again, traveling to Florida to take on AFC South counterpart Jacksonville on Sept. 29.