Khaled Holmes won't practice at least Wed.

INDIANAPOLIS -- Indianapolis Colts center Khaled Holmes won’t be on the practice field until Wednesday at the earliest, according to Colts coach Chuck Pagano.

“He’s working with the trainers right now,” Pagano said. “They’ve had him on the grass some. I don’t anticipate him doing anything other than work with our medical staff still on Sunday and Monday. Kind of keeping our fingers crossed and hopeful he’ll be out there ready to get some snaps on Wednesday is the goal.”

Holmes sprained his ankle in the preseason opener against the New York Jets on Aug. 7. Wednesday would be the first time he has practiced since the injury.

There’s still no guarantee that Holmes will be ready for the season opener against the Denver Broncos on Sept. 7.

“You just have to take it day-by-day, see how he progresses,” Pagano said. “If he’s able to get out there Wednesday and see, post practice and then the next day, how he comes in and how he reacts to the work. That’ll just be day-to-day.”

Holmes’ backup, Jonotthan Harrison, did not play against the Cincinnati Bengals because of an injured thumb. Rookie Jack Mewhort slid over from guard and started at center against the Bengals.

“We’ll make no excuses,” Pagano said. “Whoever we go out to Denver with, we’re going to line up and they’ll compete and they’ll play at a high level.”