In five career games, Fitzgerald has nine touchdowns against the Eagles, the most against any team outside the NFC West. If Fitzgerald catches a touchdown Sunday at Lincoln Financial Field, it'll be the third straight season he's scored against the Eagles.
But there's nothing special about the Eagles, according to Fitzgerald.
"Just an anomaly," he said. "I don't know, lightning strikes twice every once in a while in the same place. But I don't really focus too much on it. It's just the next team on the schedule.
"My complete focus is on playing at my best every single week. I wish I could have that kind of success against every franchise. I don't look at it any different."
Fitzgerald's abuse of the Eagles began in his second season, when he had 93 yards and a touchdown on five catches in 2005. And for the next three games, one touchdown wasn't enough. He had two in 2008, three in the 2008 NFC Championship Game and two more in 2011.
In last season's win over Philadelphia at University of Phoenix Stadium, Fitzgerald caught just one touchdown but finished with 114 yards -- one of two 100-yard games last year.
There are two other streaks on the line Sunday.
He's aiming for his fourth-straight 100-yard game against the Eagles and his third consecutive offensive player of the week honors after facing Philadelphia.
"I think some guys have some team's number," Arizona coach Bruce Arians said. "Having never been a part of [a Cards-Eagles game], I think it's hard for me to say. I think that Larry is playing very well right now and I would anticipate him having a very good game right now, also."