That altered the course of Oklahoma State's season and has the Cowboys in position to capture the Big 12 South.
Now, he's made another play that might alter the season. Oklahoma quarterback Landry Jones made a poor decision to force a pass to Ryan Broyles, but was intercepted by Lewis, who returned it 52 yards for a game-changing score.
Oklahoma State could be down 21-3. In a blink, the Cowboys trail just 14-10. And once again, Lewis is to thank.