Like quarterback and fellow Notre Dame transfer Dayne Crist, Ragone has completed his undergraduate degree at Notre Dame and will be immediately eligible.
Ragone's career has been plagued by knee injuries, but he came to Notre Dame as the nation's No. 2 tight end and the nation's No. 55 overall prospect.
He'll be counted on to produce a solid replacement for Tim Biere, who graduated from KU after last season.
Ragone had 11 catches for 109 yards in 37 games over five seasons at Notre Dame.
The New Jersey native missed the entire 2008 season and 10 games of the 2011 season with knee injuries.
Ragone's move makes it six transfers from FBS schools since Weis took over at Kansas. KU's latest recruiting class features just 11 high school players, with nine juco transfers and the six FBS transfers.