Held to 24 yards on eight carries in the first half, Williams was hit hard on a 5-yard run on the Eagles' first play after receiving the third-quarter kickoff. He eventually went to the locker room. There was no word from the team on his status.
Andre Williams scored this 26-yard TD but otherwise struggled against Syracuse's stout run defense.
Williams had averaged 299 yards rushing the past three games to put him at 2,073 yards and ramp up the Heisman Trophy talk for the senior.
He finished with 29 yards on nine carries. Both totals were season lows, and Saturday was only the third time he failed to crack the 100-yard mark in an otherwise stellar regular season. He eclipsed the 200-yard threshold five times, including a school-record 339 yards against North Carolina State on Nov. 16.
Williams scored the game's first touchdown on a 26-yard scamper to give BC an early 7-0 lead with 1:47 left in the first quarter, but he was otherwise throttled by Syracuse's defense.
After he exited the game, the Eagles finished a nine-play, 70-yard drive to tie the game at 21-21.
The teams traded leads before Orange quarterback Terrel Hunt hit tight end Josh Parris with an 8-yard touchdown pass with 6 seconds remaining, and Syracuse stunned BC 34-31 on Saturday to become eligible for the postseason for the third time in four years.