All three players were downgraded to out because of injuries. Spikes has been hobbled with knee and ankle injuries, while Dennard hurt his right knee in the second quarter of Sunday's loss to the 49ers. Gronkowski has been out with a broken left forearm since Nov. 18.
With Spikes out, the Patriots have a few different options.
Mike Rivera, a first-year player from Kansas, started in place of Spikes last Sunday. Rivera played just the first series before giving way to Spikes.
At right cornerback, Kyle Arrington is the top backup to Dennard. That would be the likely change there, unless the Patriots consider moving Devin McCourty from safety to corner and inserting Patrick Chung into the safety mix.
Gronkowski's absence likely means that Michael Hoomanawanui assumes the No. 2 spot on the tight end depth chart, which he's held the last two games.