Rapid Reaction: Twins 8, Red Sox 6

MINNEAPOLIS -- Red Sox reliever Andrew Miller had not given up a home run this season. Chris Parmelee had not hit one.

Both of those statements were nullified with one swing, Parmelee connecting off Miller for a walk-off two-run home run in the bottom of the ninth to give the Minnesota Twins an 8-6 win over the Red Sox.

Miller, who entered at the start of the ninth, struck out the first two batters he faced before Kurt Suzuki grounded a single just out of the reach of third baseman Will Middlebrooks. The left-handed hitting Parmelee took a strike, then launched a fastball down-and-in deep into the right-field seats.

Miller had given up just two hits in 21 previous at-bats to left-handed hitters this season.

Ortiz trumped: The Twins’ walk-off win nullified a big night for David Ortiz, who hit two bases-empty home runs and two run-scoring singles, the first time in his career that he has had four run-scoring hits in the same game.

Thwarted comeback: The Sox trailed 5-1 after two innings, the Twins bunching four hits and two walks to score five in the second off Sox starter Jake Peavy, who gave up a home run to Eduardo Nunez in the inning. The Sox scored on Ortiz home runs in the first and fourth, and scored a third run when Shane Victorino tripled in the sixth and scored on Ortiz’s RBI single to left.

The Sox tied the score with three runs in the seventh, six straight Sox batters reaching against three Twins relievers, the last Jonny Gomes on a full-count walk to force in the tying run.