Henderson stepped in for Cordy Glenn, who did not participate in team drills Wednesday. Glenn missed Tuesday's practice with an illness, but was replaced by Chris Hairston with first-team. On Wednesday, Hairston split reps at right guard with Kraig Urbik.
Henderson, a seventh-round pick, did not practice Tuesday because of travel-related issues, but was thrown into the fray Wednesday.
Tight end Scott Chandler (excused for family matter) remained out of practice, the only player on the Bills' 90-man roster not spotted Wednesday. Cornerback Darius Robinson, wide receivers Cordell Roberson, Marcus Easley, and Ramses Barden, and defensive end Bryan Johnson were all limited in practice.
The highlight of Wednesday's practice was the two-minute drill that ended the session. EJ Manuel looked sharp, completing consecutive passes for first downs to Robert Woods and Chris Hogan, pushing the first-team offense to the 20-yard line with 30 seconds left.
However, the offense struggled from there with two sacks setting up a third-and-11, and Hogan couldn't get a hold of a pass across the middle. On fourth down, Manuel fired a well-thrown pass into the corner of the end zone, intended for Woods, but cornerback Nickell Robey leaped in front of it for an interception.
Robey briefly remained on the ground before walking off the field with trainers. He appears to have dodged a serious injury on the play.