"There won't be a sellout," Brandon told WGR 550 on Wednesday. "The game will be blacked out."
Brandon noted that December games at Ralph Wilson Stadium have usually been difficult to sell out.
"Typically early in the season, we don't have issues moving tickets," he said. "But regardless of opponent, December games even going back to the 1990s have been historically difficult to sell. I think we sold out 63 percent of those games in December in the '90s and about 67 percent in the 2000s in December."
The Bills played one of their home games in Toronto earlier this month. Had that game been at Ralph Wilson Stadium, Brandon said it would not have sold out, either.
"Much like a couple weeks ago, if [the Atlanta Falcons] were here, that game would not have sold out either," he said. "If that's part of the process, what we've talked about, playing meaningful games in December certainly assists with that and hopefully we'll be seeing more of those down the road."
When the Dolphins improved to 8-6 last Sunday, the Bills were officially eliminated from the playoffs. Earlier this year, Brandon said his team's goal this season was to make the postseason.
"That was our stated goal. I said it and I stand by it," he said. "It certainly was a disappointing season for us, for our fans, for our sponsors, everyone that supports us."