Middle linebacker Luke Kuechly, center Ryan Kalil and fullback Mike Tolbert were named first team. Defensive end Greg Hardy, who tied the team single-season record for sacks (15), was named to the second team.
Quarterback Cam Newton, who was selected with those four to the Pro Bowl last week, was not named to the team.
It was the first time Kuechly, Tolbert and Hardy were selected to the team. Kalil was named to the second team in 2011.
The three first-team selections tied the team record set in 1996. The 2008 team also had four All-Pros, two on the first team and two on the second.
"All four have worked very hard, have done a great job for us,'' coach Ron Rivera said on Friday. "I am disappointed for a number of guys, though. We had some guys that played well that deserved recognition as well.''