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Five nuggets of knowledge on Week 16:

Busted rivalry: When the NFL released its schedule this spring, many of us had high expectations for a late-December matchup between the Green Bay Packers and Chicago Bears. Instead, an injury-devastated Bears team will limp north as a (deserved) 13-point underdog. It's possible the Packers will have clinched home-field advantage even before taking the field Sunday night, if the San Francisco 49ers lose Saturday at the Seattle Seahawks. If not, the Packers will attempt to secure it against a team playing without quarterback Jay Cutler, running backs Matt Forte and Marion Barber, and receiver Johnny Knox. Third-string running back Kahlil Bell is expected to start, pairing with third-string quarterback Josh McCown -- who has a history of helping the Packers' playoff positioning. (See: Noooooooooooooooo!) One other interesting bit of history: The Packers are one of five teams in NFL history to open a season 13-0 and then lose in their 14th game. All four of the other teams lost their 15th game, too. That list includes the 2009 and 2005 Indianapolis Colts, the 2009 New Orleans Saints and the 1998 Denver Broncos.

Packers' run game: For several reasons, Sunday night's game would be an obvious target for the Packers to try to enhance their running game. James Starks (ankle) and Brandon Saine (concussion) are expected to return. The Packers will start a makeshift offensive line that likely will include T.J. Lang at right tackle and Evan Dietrich-Smith at left guard; the best way for offensive linemen to get comfortable is via run blocking. And it's also worth repeating that the Bears historically have done a good job limiting Packers quarterback Aaron Rodgers' downfield opportunities. According to ESPN Stats & Information, Rodgers has completed only five of 26 attempts on throws against the Bears that traveled in the air 21 yards or more. He's thrown for one touchdown, a game-winner to receiver Greg Jennings in 2009, and two interceptions on those passes.

Detroit's challenge: The Detroit Lions will clinch a playoff spot Saturday if they beat the San Diego Chargers in what will likely be a raucous atmosphere at Ford Field. (There are also several scenarios to clinch this weekend even if they lose. They're noted in this post.) Hopefully everyone knows the Chargers are on one of their annual December rolls. They've won three consecutive games after a six-game losing streak. Since Norv Turner took the head coaching job in 2007, the Chargers are 20-2 in December. This will be no cakewalk.

Big targets: Chargers quarterback Philip Rivers struggled earlier this season, but he has been the NFL's most efficient quarterback over the past three weeks based on Total Quarterback Rating. Rivers has hit a groove with a pair of 6-foot-5 receivers that will pose significant matchup problems for the Lions. Malcom Floyd has 11 receptions for 233 yards and two touchdowns over the past two games, while Vincent Jackson has caught 12 passes for 211 yards and a touchdown. Jackson has been sidelined in practice this week by a groin injury. Lions cornerback Chris Houston (knee) clearly wasn't 100 percent last week against the Oakland Raiders, and the team re-signed Brandon McDonald this week for extra depth. Safety Louis Delmas (knee) also remains sidelined, and backup Chris Harris was cleared Thursday to practice following a concussion.

Make it stop: If you're a big-picture observer, you see ample motivation for the Minnesota Vikings to lose Sunday at the Washington Redskins. One more victory by the Indianapolis Colts, in conjunction with two more Vikings defeats, would give the Vikings an excellent chance to secure the No. 1 overall pick of the 2012 draft. A loss to the Redskins would extend the Vikings' losing streak to seven games, tying a franchise record set in their expansion season of 1961. But I'm not sure what would be worse: tying that record or extending their NFL record of games without an interception, which stands at nine. Redskins quarterback Rex Grossman has thrown at least one interception in his past 10 starts, and he is tied for the second-most interceptions in the NFL (18) despite missing three games this season. Something's got to give.