Melton, who entered the game second on the Bears with 4.5 sacks, was on the field to start the second half.
No announcement was made in the press box regarding the injury as the Bears went into halftime with a 31-5 lead over the Tennessee Titans.
Meantime, Bears defensive end Israel Idonije suffered a left leg injury earlier in the second quarter while attempting to tackle Titans running back Chris Johnson, but he did return to the field for the final defensive play of the half.
Idonije remained on the ground for over a minute after the injury before he walked off the field slowly under his own power. Upon reaching the Bears' sideline Idonije immediately went to the trainers table where he had his left shoe re-taped by the team's medical staff.
Idonije was credited with a 12-yard sack on Titans quarterback Matthew Hasselbeck earlier in the game.