Because the entire group hasn’t yet played an entire game together, not to mention the fact Chicago has overhauled its scheme, the defense won’t come out the gates playing lights out. But it'll play well enough to force EJ Manuel to make mistakes.
Offensively, despite Santonio Holmes’ inexperience with the system, the Bears should be able to get him up to speed enough to contribute because the playbook narrows with the team game planning. Look for a crisp outing from Jay Cutler, who is now in Year 2 of Marc Trestman’s offense. He’s showing complete command of the system.
Buffalo’s defense will hold its own early on, but Chicago’s defense -- despite struggling in the preseason -- should be able to force Manuel into mistakes and turnovers that will put the offense in ideal situations.
My prediction: Bears 31, Bills 13