Plesac, who did not return calls seeking comment, has been a mainstay at MLB Network since its inception and is in the middle off a long-term contract.
A former closer, Plesac spent 18 years in the major leagues, including two seasons with the Cubs in 1993-94. He still holds the Milwaukee Brewers' all-time record for appearances by a pitcher with 365.
A Northwest Indiana native, Plesac, who did pre- and postgame analysis on Comcast SportsNet Cubs broadcasts before joining the MLB Network, would have to be considered one of the favorites for the job.
The Chicago Sun-Times reported last week that another former Cub, Eric Karros, will be interviewed as well.
The vacancy was created when Bob Brenly and WGN Television failed to come to terms on a contract extension last month. Brenly signed as a color commentator with the Arizona Diamondbacks after eight seasons in the booth with play-by-play man Len Kasper.