Rapid Reaction: White Sox 6, Cubs 4

CHICAGO -- Here's a quick look at the Chicago Cubs' 6-4 loss to the Chicago White Sox on Friday:

How it happened: Cubs starter Randy Wells, sailing through six innings after surviving a two-run first inning, hit a roadblock in the seventh. He gave up a two-run home run to Alexei Ramirez to tie the game 4-4 and then allowed a two-run triple to Juan Pierre to fall behind 6-4. Cubs manager Mike Quade had no answer in the bullpen for left-handed pinch hitters Adam Dunn and Pierre coming up in the seventh.

What it means: The Cubs continue to stumble in pursuit of winning three games in a row for the first time all season. They have won two straight eight times, and are the only team in baseball without a three-game winning streak. The Cubs have dropped three of four to the Sox.

Outside the box: Aramis Ramirez's 300th career home run was wasted in the loss. In his past 24 games, Ramirez has hit nine home runs and driven in 21 runs while batting .305, according to ESPN Stats & Info. Carlos Zambrano's sore back landed him on the disabled list. Veteran Ramon Ortiz will most likely start for Zambrano on Tuesday. Out since May 21 since getting beaned, rehabbing outfielder Marlon Byrd may re-join the Cubs this weekend.

Next: The Cubs' Matt Garza (4-6, 4.07) takes on Phil Humber (7-4, 2.89) in Game 2 of the series at 3:10 p.m. CT Saturday.