All three of Reed's blown saves this season have come in games started by Quintana, including two in the past month as Quintana suffered through a five-start winless stretch.
Quintana worked 6 2/3 innings for his first win in more than a month, Reed earned his second four-out save of the season and the Chicago White Sox held off the Toronto Blue Jays 3-2 Tuesday night for a rare victory at Rogers Centre.
"It kind of meant a little more," Reed said of his 21st save in 24 chances. "I was trying to get (Quintana) the win today. It was nice to settle it up for him."
The AL Central leaders won in Toronto for just the fourth time in 20 games dating to 2007.
"It was good for us, a big win," White Sox manager Robin Ventura said.
Quintana (5-2) allowed two runs and eight hits to win for the first time since July 5 against Texas.