Rapid Reaction: White Sox 6, Red Sox 4

CHICAGO -- The Chicago White Sox started an eight-game homestand, and a 10-game run in the Chicago city limits, with a 6-4 victory Monday over the Boston Red Sox.

How it happened: Adam Dunn hit a three-run home run in the first inning, and the White Sox never looked back. Alejandro De Aza, Alexei Ramirez and Dayan Viciedo added RBIs. Dylan Axelrod threw just 83 pitches, but gave up only two runs on four hits over six innings. The White Sox improved to 5-4 against American League teams that started the day in either first or second place. Red Sox starter Jon Lester entered with a 5.20 ERA against the White Sox, his highest against any AL team.

What it means: The White Sox continue to show strides offensively, although in reality, they had nowhere to go but up. After rebuilding his swing from the ground up, Dunn hit his fifth home run over his past seven games. Dunn entered just 2-for-29 against left-handed pitching this season, and was just 1-for-6 against Lester in his career.

Outside the box: After entering with the worst slugging percentage against left-handers in the American League (.345), not to mention the least amount of runs scored against them by far (28), the White Sox got to the lefty Lester with some left-handed bats. Dunn and De Aza drove in the first four runs. It was the first loss of the season for Lester (6-1), who had attempted to become the first Boston lefty starter to open the season 7-0 since 1973.

Off beat: Matchups against AL East teams haven’t always gone well for the White Sox in recent years, but they are now 5-4 against the division this year. Since 2011, Chicago is now 41-45 against the AL East, going 19-25 at home and 22-20 on the road. The White Sox are 3-6-1 over their past 10 home series against AL East teams.

Up next: The White Sox will send left-hander Jose Quintana (2-1, 3.97 ERA) to the mound against Boston in the middle game of the three-game series. The Red Sox will counter with left-hander Felix Doubront (3-1, 6.03) in the 7:10 p.m. start from U.S. Cellular Field.