The 10-point victory is the second-largest margin of victory for a 15-seed over a 2-seed. Only Coppin State's 13-point win over South Carolina in 1997 was larger.
The only teams to defeat a 2-seed in their first ever NCAA tournament game were 2001 Hampton (versus Iowa State) and 2012 Norfolk State (versus Missouri).
Being upset early has become a common theme for Georgetown. The Hoyas are the first team to be eliminated in four straight NCAA tournaments by a team seeded at least five spots lower.
Margin of Victory: 15-seed vs. 2-seed
Florida Gulf Coast
How did FGCU get it done?
The Eagles outscored Georgetown 25-11 in transition. Their 25 transition points were the most the Hoyas have allowed in a game this season; they entered the game allowing 10.1 per game.
Otto Porter Jr. could not finish around the rim, making two of his nine field goals in the paint.
The Eagles have their work cut out for them if they want to keep wearing the glass slipper. No 15-seed has ever made it to the Sweet 16. Coppin State in 1997 was the only 15-seed to even come within 10 points of its Round of 32 opponent. Norfolk State and Lehigh lost by a combined 46 points last year.
Other notes from Friday
North Carolina coach Roy Williams earned his 700th career win in UNC's win over Villanova.
La Salle advanced to the Round of 32 for the first time since 1990. The Explorers have won two games in the same NCAA tournament for the first time since 1955.
Miami defeated Pacific by 29 points for the Hurricanes' largest margin of victory in an NCAA tournament game in school history.