- Jeff Barlis, College Football
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Florida Atlantic at No. 2 Alabama, SEC Network
This one could get ugly, as the Crimson Tide defense -- the secondary, in particular -- looks to bounce back and earn some trust from coach Nick Saban after last week's too-close-for-comfort 33-23 win over West Virginia. The Owls, who lost 55-7 in their season opener at Nebraska last week, should be just what Alabama needs in its home opener. All eyes will be on Bama's quarterbacks after Saban said he would "probably" play ballyhooed backup Jake Coker along with Blake Sims, the starter. Sims was solid as a game-manager type in Week 1, but if he slips at all, Coker could make a bid for the starting job.
No. 24 Missouri at Toledo, ESPN
Gary Pinkel was the coach at Toledo from 1991 to 2000 before taking the same position at Missouri, so he's doing his old school a solid by playing on the road this week. Toledo played at Mizzou last season and lost a competitive game 38-23, but this version of the Rockets is improved. Quarterback Phillip Ely, an Alabama transfer, threw for 337 yards and four touchdowns in the Rockets' season-opening 54-20 win against New Hampshire. The Tigers are just a five-point favorite in this game, according to Bovada. Missouri QB Maty Mauk and Co. will look to continue their big-play ways, but Toledo is one of just two teams that hasn't allowed a touchdown of 40 yards or more since the start of the 2013 season.
Arkansas State at Tennessee, SEC Network
The Vols opened some eyes with a convincing 38-7 victory in their opener against Utah State. Particularly impressive was their defense, which held Utah State and dangerous dual-threat quarterback Chuckie Keeton to 244 yards of total offense. The Volunteers will need a repeat performance against an Arkansas State offense that should not be overlooked. The Red Wolves have been to bowl games in each of their past three seasons and added the formidable offensive mind of coach Blake Anderson, formerly the offensive coordinator at North Carolina.
2 p.m. ET
UAB at Mississippi State, ESPN3.com
MSU had a terrific opening week. We knew the defense was one of the best in the SEC, but quarterback Dak Prescott and the Bulldogs' offense showed a lot of bite in a 49-0 rout of Southern Miss. Prescott threw for a career-high 284 yards, and two of his four passing touchdowns went to electric athlete De'Runnya Wilson. Mississippi State faces another Conference USA foe this week in the Blazers, who could provide more of a test for MSU's run defense. UAB rushed for 338 yards in a 48-10 Week 1 win against Troy, including Jordan Howard's standout effort (179 yards and two TDs).
3:30 p.m. ET
Ohio at Kentucky, ESPNU
The Wildcats kicked the basketball offseason to the back burner last week when their fast-breaking offense captured everyone's attention in a 59-14 feel-good win against Tennessee-Martin. The 59 points were especially crowd-pleasing after Kentucky averaged just 20.5 last season. Sure, Tennessee-Martin offered little resistance, but UK quarterback Patrick Towles showed a command of the offense in his first start, racking up 377 yards passing. The only downer for the Cats is that former Nebraksa transfer RB Braylon Heard, who dazzled last week with touchdown runs of 73 and 43 yards, is doubtful with an ankle injury.
4 p.m. ET
Eastern Michigan at Florida, SEC Network
The Gators are chomping at the bit to play after last week's deluge wiped away their season opener against Idaho. And guess what? There's a 50 percent chance of thunderstorms on Saturday as well. Because this will be Florida's first game of the season, it's worth noting that UF has the nation's second-longest winning streak in season openers with 24 (behind Nebraska's 29). The Gators' defense should feast on EMU's run-heavy offense. On the other side of the ball, Florida is debuting a no-huddle spread offense that should better suit athletic dual-threat quarterback Jeff Driskel.
Nicholls State at Arkansas, SEC Network
The Razorbacks are riding a losing streak of epic proportions -- a school-record 10 games, dating to last season. They haven't won since Sept. 14, coach Bret Bielema's third game. Almost a year later, Arkansas has a plum chance to get off the schneid against an FCS team that will be facing an SEC foe for the first time in its history. Arkansas might have gained a measure of pride from their first-half performance at Auburn last week, but the offense generated just 61 second-half yards after piling up 267 in the first half. The defense showed it still has a long way to go, giving up 595 yards to the Tigers' offense.
4:30 p.m. ET
No. 15 Ole Miss at Vanderbilt, ESPN
Finally, a competitive game to discuss. This week's sole conference matchup pits permanent interdivision rivals who have been separated by a total of five points in their past two meetings. Ole Miss won last season but is just 1-9 in its past 10 conference openers. These teams have something in common. Vanderbilt would like to forget last week's embarrassing 37-7 loss to a Temple team that won just two games in 2013. Ole Miss would like to forget the first 3½ quarters its offense needed to get back on track against Boise State. Rebels QB Bo Wallace had 387 yards and four touchdowns passing last week but raised some eyebrows with three first-half interceptions.
7 p.m. ET
San Jose State at No. 5 Auburn, ESPN2
Nick Marshall makes his first start of the season at quarterback for the Tigers. He sat the first half last week as punishment for being cited for marijuana possession in July. His understudy, Jeremy Johnson, impressed in Auburn's season-opening win against Arkansas and will surely see time in this one, even if it's just garbage time. The Spartans are an improving Mountain West program, but their SEC history has been flat-out ugly. They have played SEC teams four times and lost all four, giving up 113 points (while scoring just six) in their past two meetings with SEC foes.
East Carolina at No. 21 South Carolina, ESPNU
The Gamecocks heard all offseason about what a dangerous and underrated opponent they've got in Week 2. But South Carolina was humbled last week in the first national spotlight game of the young season and should have every motivation to rebound in a big way against the Pirates. After getting torched for 680 yards and 52 points by Texas A&M's offense, South Carolina has to shore up its pass defense against ECU quarterback Shane Carden, who threw for a school-record 4,139 yards last season and led the Pirates to 10 wins. Gamecocks QB Dylan Thompson and his offensive line performed well in Week 1. This one's all on the defense.
7:30 p.m. ET
Lamar at No. 9 Texas A&M, SEC Network
Who's this Lamar fella and how is he going to keep up with Kenny Hill? In all seriousness, the Lamar Cardinals are a middling FCS program based in Beaumont, Texas. This game promises to be a lopsided affair, but at least Hill likely won't have to play all four quarters. Before his record-breaking coming-out party against the Gamecocks, Hill supposedly was in a close competition for the starting job with talented true freshman Kyle Allen, the No. 1 rated quarterback coming out of high school last year. If Hill plays anywhere close to the level of his debut, Allen should get some quality time with A&M's voluminous weapons.
Sam Houston State at No. 12 LSU, SEC Network
Coming off a dramatic comeback win against then-No. 14 Wisconsin last week, it just doesn't seem fair for the Tigers to face an FCS opponent in Death Valley. The Bearkats are averaging more than 600 yards of offense in their first two games. But LSU has played FCS opponents six times in Les Miles' nine years and outscored them by a combined 232-64. The real intrigue here is the Tigers' QB situation. Sophomore starter Anthony Jennings completed less than half of his attempts last week, but freshman Brandon Harris looked worse in his only series.
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Noon ETFlorida Atlantic at No. 2 Alabama, SEC NetworkThis one could get ugly, as the Crimson Tide defense -- the secondary, in particular -- looks to bounce back and earn some trust from coach Nick Saban after last week's too-close-for-comfort 33-23 win over West Virginia.