Wayne Ellington added 16 for the Nets, who had lost to Fenerbahce Ulker of Turkey on Monday in their exhibition opener.
NETS: Chris Daniels, a 31-year-old rookie, hit a pair of 3-pointers in the fourth quarter. . Lopez grabbed nine rebounds.
KEY RETURN: Detroit point guard Reggie Jackson returned to the lineup after missing Tuesday's game with Achilles soreness and scored seven points in 29 minutes.
FRUSTRATION: The Pistons turned the ball over 18 times in the first half, visibly angering Stan Van Gundy, but only had four in the second half.
UP NEXT: Both teams play again on Saturday. Detroit visits Milwaukee and the Nets are in Philadelphia.