Soto misjudged a line drive off the bat of Ian Kinsler with one out and the bases loaded with the Rangers trailing 2-1 in the bottom of the second. Mitch Moreland came home from third with the tying run, but Soto also should have scored from second base on a ball that caromed off the top of the out-of-town scoreboard in left field.
The Rangers didn't score any more runs in the inning and missed out on a chance to gain momentum against one of the American League's toughest pitchers, White Sox left-hander Chris Sale.
"I read the ball badly," Soto said. "I just thought he hit it with top spin when he hit the ball. I thought it was going to come up short and [Alejandro De Aza] was going to make a catch on the warning track, but it wasn't that way.
"I should have been halfway between the base line and see the result of the play and go accordingly. Even if he catches it, I'm still in scoring position. But he didn't. I should have scored on that play."
Sale was able to settle in and retire 10 straight Rangers after Kinsler's long single. Sale went seven innings, matching his season high with seven strikeouts. The Rangers didn't get another runner in scoring position against him.
The Rangers missed out on a chance to pick up Soto after his baserunning error. Elvis Andrus struck out after a nine-pitch faceoff with Sale, failing to score a runner at third with one out to give the Rangers the lead. Lance Berkman grounded into a fielder's choice to end the rally.
"We still had the bases loaded and one out," Soto said. "We could have capitalized. But definitely a running mistake on my part. That didn't help."
Soto did an admirable job of guiding rookie starter Nick Tepesch through a tough beginning when he allowed a run each in the first two innings to fall behind 2-0. Soto and Tepesch went away from his fastball and relied heavily on his slider and sinker as he threw four scoreless innings from the third to the sixth.
The White Sox finally got to Tepesch with two home runs in the top of the seventh. White Sox third baseman Conor Gillaspie led off the inning by belting a 1-0 change-up into the Rangers' bullpen in left-center field for a 3-2 lead. Tepesch later hung a slider that De Aza hit for a two-run home run for key insurance runs with two outs in the inning.
"He just left it up a little bit," Soto said. "He pitched with his heart. He pitched with poise, and you can see that. Just one pitch. That's how games go."