Matthew Stafford, QB, Detroit Lions: Stafford, who led the Lions to a 45-14 rout of the Eagles on Thursday, had his best game of the season, throwing for 337 yards and five touchdown passes and racking up 34 fantasy points. It was only his second game of the season with more than 30 fantasy points, as he put up 33 in an overtime win over the Bears in Week 6.
Calvin Johnson, WR, Detroit Lions: Stafford's favorite receiver also had his best game of the season against the Eagles' porous pass defense. He caught eight passes for 93 yards with three touchdowns, good for 27 fantasy points. Coming into Thanksgiving Day, Johnson had just three TD catches in the first 10 games of the season.
Tony Romo, QB, Dallas Cowboys: Romo struggled against the Panthers on Thursday before he left the game with a left collarbone injury in the third quarter. He was 11-of-21 passing for 106 yards and three interceptions, two of which were returned for a touchdown. He had minus-two fantasy points.
Dez Bryant, WR, Dallas Cowboys: Bryant managed just two catches and 26 yards against the Panthers, despite being targeted eight times. He finished with only two fantasy points. Tight end Jason Witten didn't have a great night, either. He had just four catches for 36 yards.
DeMarco Murray, RB, Philadelphia Eagles: Murray rushed 14 times for 30 yards -- an average of 2.1 yards per carry -- in the loss to the Lions, putting up just three fantasy points. It was also the first time this season that he failed to catch a pass.