Keenum, making just his second start against the Colts, finished the game 20-of-34 for 350 yards and three touchdowns.
The Colts feel more prepared to face Keenum, who replaced veteran Matt Schaub, this time around becuase they have more footage of him.
"Have to get him under wraps," linebacker Robert Mathis said. "You just can't let him get going and knowing he's the engine that drives their offensive machine. So, have to stay on him just as much as we can."
The Colts didn't get much pressure on Keenum, sacking him only once in the first game. You can expect them to try to rattle him some. The defense needs a bounce-back performance after allowing Cincinnati quarterback Andy Dalton to sit back in the pocket and pick them apart and eventually win AFC Offensive Player of the Week honors. The Colts have given up an average of 31 points and 401 yards per game in the past seven games.
Keenum has completed 54 percent of his pass attempts and thrown for 1,592 yards with nine touchdowns and four interceptions. He's also been sacked 15 times in seven games this season.
"He's obviously had ups and downs as a young quarterback," Texans interim coach Wade Phillips said. "He's had brilliant time, certainly the first half against the Colts. But he had a tough time in the second half against them, so he's learning as he goes. But he's got talent. He's got talent to make big plays when everything's broken down, so that's what we like about him."