Jacksonville Jaguars: LaRon Landry

JACKSONVILLE, Fla. -- The Jacksonville Jaguars are now down two starters in the secondary after safety Dwight Lowery was ruled out of Sunday’s game with Indianapolis because of a concussion.

Lowery suffered the injury early in the Jaguars’ 45-17 loss to Seattle last Sunday. He was replaced by rookie Josh Evans, the team’s sixth-round draft pick, and Evans will start in Lowery’s place. The Jaguars are already without starting cornerback Dwayne Gratz because of a high ankle sprain.

There is some good news for the struggling offense because tight end Marcedes Lewis is set to make his season debut on Sunday. He’s a reliable, familiar target for quarterback Blaine Gabbert, who was announced as the starter on Monday after he missed the past two games because of a cut on his right hand.

Lewis will need to have an impact in the passing game because the Jaguars (0-3) will be without receivers Stephen Burton (concussion-like symptoms) and Mike Brown (back). Justin Blackmon is also serving the final game of his four-game suspension for violating the league’s substance-abuse program.

The Colts (2-1) will be without running back Ahmad Bradshaw (neck), defensive end Ricky Jean-Francois (groin) and safety LaRon Landry (ankle).

Get to know the Indianapolis Colts

September, 24, 2013
9/24/13
4:15
PM ET
The Jacksonville Jaguars return home after spending more than a week on the West Coast, suffering losses to Oakland and Seattle. They will next face the Indianapolis Colts, who they’ve beaten in three of the past four meetings, in an effort to halt an eight-game losing streak that dates back to last season.

The Colts and Andrew Luck are coming off a surprising 27-7 rout of host San Francisco last week. They held the 49ers to 254 yards of total offense and neutralized Colin Kaepernick on the ground, holding him to just 20 yards.

Kickoff is set for 1 p.m. ET and the game will be televised on CBS.

Here’s a look at the Colts:

Record: 2-1.

Last week: Beat San Francisco 27-7.

[+] EnlargeChuck Pagano
Kyle Terada/USA TODAY SportsChuck Pagano coached the Colts to a surprising 27-7 win over the 49ers in San Francisco.
Coach: Chuck Pagano, second season (13-6).

Offensive coordinator: Pep Hamilton.

Defensive coordinator: Greg Manusky.

Series record: Colts lead 16-8.

THREE PLAYERS TO KNOW ON OFFENSE

QB Andrew Luck: Forget his passing yards, touchdowns or ability to make all the throws. The most impressive thing about Luck is his ability to come through in the clutch. He has started 20 games and has led the Colts to eight game-winning drives in the fourth quarter or overtime.

RB Trent Richardson: The Colts acquired him in a trade last week and all he did was score a touchdown on his first carry. Richardson is a power runner and should, when he has completely learned the offense, provide the balance the offense needs. Provided, of course, he stays healthy.

WR T.Y. Hilton: The second-year player is averaging a team-high 14.3 yards per catch, and his 10 catches are second only to Reggie Wayne’s 11.

THREE PLAYERS TO KNOW ON DEFENSE

DE Robert Mathis: He leads the team with 4.5 sacks and his 96.0 career sacks rank second in Colts history behind Dwight Freeney (107.5). Mathis has the fourth-most sacks of any player in the NFL since he joined the league in 2003. He has recorded 9.5 sacks in his career against the Jaguars, second only to the 15.5 he has recorded against Houston.

LB Jerrell Freeman: The former undrafted player from Mary Hardin-Baylor toiled for several seasons in the CFL, where he led the league in tackles in 2011, before landing with the Colts in 2012. He’s been an instant impact player. He not only leads the team with 29 tackles, he also has three sacks and has forced two fumbles.

S LaRon Landry: He is second on the team with 26 tackles despite missing the San Francisco game with an ankle injury. He is expected to return this week.

ETC.

The Colts have turned the ball over only once this season. The Chiefs and Titans are the only teams in the league that have not committed a turnover. … The Colts have also only dropped one pass. ... If the Colts rush for more than 100 yards this week, it will mark the first time since 1988 the team has done that in the first four games of the season. … Wayne has caught 133 passes for 1,856 yards in his career against the Jaguars. … Former Jaguars linebacker Brant Boyer is an assistant special teams coach with the Colts.

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