1. No Luck. How much of a problem? By now, just about everybody knows the Cardinal are without former all-everything quarterback Andrew Luck, who graduated to the NFL after last season and now starts for the Indianapolis Colts. What not everybody knows is the name of his replacement: Josh Nunes, a fourth-year player from Upland, Calif. He's been good so far, making few of mistakes that often plague first-time starters. But many of the Trojans weren't afraid to say this week that Nunes is not yet comparable to Luck. For the Cardinal, the obvious narrative after they barely snuck by the San Jose State Spartans to win their opener was growing pains with a first-year signal-caller. But Nunes demonstrated improvement against Duke in Week 2. If they were to upset the Trojans, that would obviously be a sign his growth process has accelerated quite a bit.
2. The unkind road and the unkind team. In each of the past five seasons, USC has lost either its first or second conference road game, including its first in three of the past four seasons. That's kind of an alarming statistic, and it might help explain why the Trojans are favored by single digits in most locations for this game. Of course, it's an even more unsettling stat that this season’s crop of USC seniors -- Matt Barkley included -- hasn't beaten Stanford in their college careers. That hasn't happened to a USC class with a regular opponent in more than a decade. Stanford Stadium isn't the loudest, craziest opposing atmosphere in the conference. But many of the Trojans' older players may have memories of a 37-35 loss on a game-ending field goal two years ago at Stanford enter their heads at various times Saturday.
3. A real running back. Stanford's Stepfan Taylor hasn't played like a particularly elite running back thus far this season, but he's thought of as one around the country. He may be the best back the Trojans face all year, so it could be a telling test for the USC front seven. Linemen Morgan Breslin and Antwaun Woods have played better than expected through two games. But can they keep it up when a capable, varied running game is thrown into the mix? If this is the first game this season USC sees the originally planned linebacking crew of Dion Bailey, Lamar Dawson and Hayes Pullard on the field together shortly after kickoff, can they handle the Cardinal's run game as a group? Will the Trojans' secondary be unified enough to prevent long runs?
4. Media distraction? It's easy to overstate the impact here -- and let's first clarify that few of USC's players may have even heard about what happened this week with the status of injuries and the local media – but it's quite unlikely thee events will affect play. But if Lane Kiffin were to somehow lose this week, he'd get absolutely roasted in subsequent days by the national media for worrying about the practice suspension of a local reporter in the middle of an important game week. He'll of course say it wasn't a distraction, but the results will stand alone. It's kind of a ready-made critique of a college football coach: If they don't win, what's the point of being so secretive about your players' injuries, anyway?
5. The tandem. Most in-game signs are pointing to Silas Redd 's eventual takeover of the Trojans' No. 1 running back role and Curtis McNeal's quiet demotion to the second spot. If it's going to happen, this will be the week it does, with USC needing to establish a consistent run game early against Stanford's solid defense. Then again, there's always the possibility that Kiffin has been keeping McNeal extra fresh, what with 16 carries in two games, so he can succeed in a game like this one. If Redd again gets 60 to 70 percent of the total carries and performs well, it's safe to assume he's USC's top back -- regardless of whether he's officially defined as such by Kiffin and Co.
Prediction: USC 41-30.