Why Clemson will win: Defense. It wins championships, right? It will win this game for the Tigers, who led the nation in tackles for loss last season and return every single major contributor to the group. An improved front seven means better results slowing down Todd Gurley and Keith Marshall, the two players Clemson needs to slow down the most. Rather than the shootout we saw a year ago, the defenses will have a much bigger role this season. Right now, Clemson is better than Georgia there, so I'm calling for the upset.
-- Andrea Adelson
Why Georgia will win: Early-season games against nationally recognized teams have not been kind to Georgia coach Mark Richt over the years (see: Clemson, Oklahoma State, Boise State, South Carolina x 2), so the law of averages says he has to win some, right? Well, there's more than just cosmic balancing in the Bulldogs' favor. While the Tigers made huge gains on defense a season ago, they also allowed an average of 38 points per game against Florida State, Georgia, Ohio State and South Carolina. We're not quite sure what to expect out of new Georgia quarterback Hutson Mason, but the duo of Gurley and Marshall at running back is unmatched anywhere else in the country. Last season's game might have played out differently had Gurley not strained a quad on a 75-yard touchdown run.
-- Jared Shanker
Why Miami will win: Duke Johnson changes everything for the Canes, as he keeps their offense moving and takes plenty of pressure off Brad Kaaya. Likewise, the loss of DeVante Parker takes plenty of punch out of Louisville's offense. A new coach, a new league and a new quarterback create too much uncertainty around a Cardinals team that has the target on its back after embarrassing Miami last time around. -- Matt Fortuna
Why Louisville will win: It's not that I'm supremely confident in this pick, but the Cardinals have a few things going for them. First, it's a marquee game for the program, its first as a member of the ACC. Secondly, while a lot has changed on defense for Louisville, it was the top-ranked rushing D in the country last season, which should help Todd Grantham's crew deal with the dynamic Duke Johnson. Most important, however, at quarterback Miami is starting a true freshman in his first career game on the road in a frenzied atmosphere. It won't be a gimme, but Louisville will pull off the victory. -- David Hale
Upset pick of the week
Why ULM will win: ULM has three advantages: It beat Wake Forest a year ago and is familiar with some of the returning personnel; the WarHawks bring back 14 starters; and they are playing at home. Wake Forest is starting true freshmen at quarterback and center. It's never easy to go on the road and make your first career start, let alone on national television. Factor in all the youth and inexperience for the Deacs, and you see why ULM has the edge. -- Andrea Adelson
More consensus picks: Syracuse over Villanova; Pittsburgh over Delaware; UCLA over Virginia; Georgia Tech over Wofford; NC State over Georgia Southern; Boston College over UMass; Virginia Tech over William & Mary; Duke over Elon; North Carolina over Liberty; Florida State over Oklahoma State