Texas was already banged up at running back.
A potentially serious leg injury to Fozzy Whittaker could put the position in further jeopardy.
Whittaker, a senior, went down in the first quarter and was attended to by trainers before leaving the game without putting weight on the leg.
Jeremy Hills is Texas' only other running back available for contributions.
Texas leads Missouri 3-0 midway through the first quarter.