Our best guess on the list for Sunday's game against the Bills:
Devin McCourty: Starting safety has missed all week of practice with a concussion. Rookie Duron Harmon is the top candidate to take his place.
Nate Solder: Starting left tackle has been on the injury report the past three weeks with a concussion. He's been limited in practice this week and more visible in the locker room, but we'll play a hunch that the team sits him out for a second straight week.
Dane Fletcher: Linebacker was a game-time decision last Sunday because of a groin injury, and didn't pass the pre-game test. If he is inactive again, it could potentially give him another two weeks to heal if the Patriots earn a first-round bye.
Shane Vereen: Running back was held out of last Sunday's win after leaving with a groin injury, and if this was the playoffs, he'd be ready to go. But the possibility of the team holding him back as a precaution makes some sense from this viewpoint.
D.J. Williams: Tight end adds a third layer of depth, and while it would be helpful to have it on the 46-man game-day roster, needs at other positions trump the luxury of a No. 3 tight end.
Jake Bequette: Second-year defensive end is fifth on the depth chart and has been inactive the past eight games.
Josh Boyce: Rookie receiver and primary kickoff returner has already been ruled for the second straight week with an ankle injury.
(Last week: 4 of 7 projections correct.)
EXTRA POINT: The Patriots have two open spots on their 53-man roster and those will likely be filled today with promotions from the practice squad (our best guesses are safety Kanorris Davis and offensive tackle Jordan Devey). Thus, a full complement of seven inactives is projected.