EAST RUTHERFORD, N.J. -- As expected, the Giants are planning to rest a lot of players in Wednesday night's fourth and final preseason game, versus the New England Patriots.

On offense, Sean Locklear will start at left tackle in place of Will Beatty; Mitch Petrus will start at right guard in place of Chris Snee; and David Wilson will start at running back in place of Ahmad Bradshaw.

On defense, Craig Marshall and Matt Broha will start at defensive end in place of Justin Tuck and Jason Pierre-Paul; Jacquian Williams and Keith Rivers will start at linebacker in place of Mathias Kiwanuka and Michael Boley; and Michael Coe will start at cornerback in place of the injured Prince Amukamara.

Here's the full list of inactives:

• CB Prince Amukamara (ankle)
• CB Terrell Thomas (knee)
• CB Bruce Johnson (shoulder)
• CB Jayron Hosley (toe)
• S Tyler Sash (ankle)
• RB Ahmad Bradshaw (hand)
• LB Michael Boley (hamstring)
• LT Will Beatty (back)
• DE Osi Umenyiora (knee)
• OT James Brewer (back)
• DT Shaun Rogers (leg)
• RG Chris Snee (leg)
• DE Jason Pierre-Paul (back)
• DE Justin Tuck (shoulder)
• LB Mathias Kiwanuka (groin)
• DE Adrian Tracy (hamstring)