PHILADELPHIA -- The Giants' secondary took another hit on Sunday night.

Safety Kenny Phillips left in the game in the first quarter with a sprained right knee. He underwent X-rays which came back negative but did not return.

"He is a big part of our defense," Justin Tuck said. "Obviously, when he goes down, somebody has got to step up but without him being out there, it kind of made us gun shy a little bit because (against) those wide receivers and that big-play offense, he is kind of like the anchor, him and Antrel (Rolle)."

The Giants' secondary has been crushed by injuries all season.

Terrell Thomas had a preseason knee injury that landed him on season-ending injured reserve. Second-year corner Prince Amukamara has dealt with a high-ankle sprain that kept him out of the first two games.

Rookie Jayron Hosley did not play in the Eagles game due to a hamstring injury. Michael Coe was questionable coming into the Eagles' game due to a hamstring injury but is active. Also, Rolle suffered a knee injury last Thursday when he collided with a television camera. He was questionable for Sunday night's game but is active.

Last, though it's not injury-related, safety Tyler Sash was suspended for the first four weeks of the season for failing a test for performance-enhancing drugs. Sash is expected to be back this week.

If Phillips can't go next week against Cleveland, Sash is a candidate to replace him.

Also on the injury front, Rolle played through a knee injury and said he came out of Sunday night's game "OK."

"I came out just as well as I walked into it. That's good," Rolle said. "There are always choices you can make. The way I looked at it, I asked myself if this was a Super Bowl game, what would I do? I would play."

PRINCE'S ANKLE IS FINE: Amukamara tweaked his ankle injury in the second half but said after the game that he was fine. In his first NFL start, the second-year corner helped hold Jeremy Maclin to one catch ... Domenik Hixon, a fixture on Giants injury reports, finished with career highs of six catches for 114 yards -- and didn't get hurt ... Running back Ahmad Bradshaw (13 rushes, 39 yards; 3 catches, 38 yards) said his neck (inflamed) felt OK after the game.