Now comes the rematch with the Redskins and a second meeting with RG3. Here are five things to watch for on Monday night:
RG3 kryptonite: The Giants barely survived RG3 the first time they faced each other. Now the Giants are the first team to get a second crack at the rookie.
Will it be a blessing or a curse? The Giants have to make the right reads and be sharp with their tackling. They have to find a way to keep RG3 from making the big play.
Griffin completed 7-of-11 passes on throws of more than 10 yards downfield against the Giants in their first meeting, according to ESPN Stats and Info. The Giants will have to keep Pierre Garcon from busting a big play.
Jason Pierre-Paul, Justin Tuck and Osi Umenyiora will have to somehow contain RG3 and get their licks in when they can. They sacked Griffin three times, intercepted him once and forced a fumble in their first meeting.
Stop Alfred: The Giants have to worry about another Redskins rookie. Running back Alfred Morris rushed for 120 yards last time these teams met, and if that happens again the Giants will be in trouble.
The Giants must be able to read when Griffin hands off to Morris and when he opts to keep it to run or throw.
Rocket science: In his last five games against Washington, Manning has thrown eight interceptions and just two touchdowns. He will have to do a much better job of exposing the Redskins' secondary and getting Hakeem Nicks and Cruz involved early and often.
Wilson's turn: It will be interesting to see how the Giants establish the running game with Andre Brown out with a broken fibula.
David Wilson is the next man up, and the Giants say his time to get carries is here. But will the coaches trust the first-round pick enough to give him meaningful carries and snaps, or will they lean heavily on Ahmad Bradshaw? And how will they utilize Wilson and get him in space?
Be the beast: The Giants have a terrific opportunity to create space between themselves and the Redskins and Cowboys in the NFC East. Of course, the Giants always seem to make life harder than it should be. A win here, though, would put the Giants in great position in the NFC East with four games remaining.