But can they bring enough pressure to bother the normally unflappable Brady?
Mathias Kiwanuka thinks so.
"I don’t care who you are, if you get hit in the face by a 300-something pound lineman, it’s going to change your day," Kiwanuka said.
Kenny Phillips agrees.
"(Brady) is very accurate but I think if we get after him we can rattle him up a little bit," he said.
The Giants defensive line has been doing an awful lot of rattling lately.
They sacked Matt Moore five times last Sunday. In their previous game, they got to Bills quarterback Ryan Fitzpatrick three times.
The Pats, it should be noted, allowed Brady to be hit four times and sacked three times in a loss to Pittsburgh last week.
Perry Fewell hinted that the Giants may borrow a page from Mike Tomlin's playbook on Sunday.
If they can identify what worked for Pittsburgh, Sunday may be reminiscent of the Giants' Super Bowl XLII performance in which they sacked Brady five times.
Fewell wasn't around in the 2007 season, but he says the approach from that day hasn't changed much.
"I wasn’t here four years ago but I will say that we do count on our pass rush to help our pass defense. We will count on our pass rush to help our pass defense again [Sunday]," Fewell said.
GILBRIDE EXCITED TO SEE JACOBS: Last week, Brandon Jacobs said he wanted the ball more. If Ahmad Bradshaw (broken foot) is out Sunday, Jacobs will get his wish.
Can he handle it? Offensive coordinator Kevin Gilbride certainly hopes so.
"What would be better than the opportunity that he’s going to get now?" Gilbride said. "He’s been clamoring for a chance. The chance is here. This is an opportunity. You want to show what you can do. I’m looking forward to seeing the way he plays. I think he’s going to respond very well. I’m excited about seeing him play."