Clayton, who has played almost exclusively on special teams, tore his meniscus and will undergo surgery on Monday. His biggest role was serving as a blocker on kick returns.
The Giants added defensive end Justin Trattou off the practice squad to the 53-man roster and signed quarterback Ryan Perrilloux to the practice squad again. This is Perrilloux's sixth practice squad stint this season.
The Giants also may be without another receiver with Mario Manningham questionable due to a knee injury. If Manningham can't play, Ramses Barden would move up as the third wideout.