FLORHAM PARK, N.J. -- Jets safety Eric Smith will miss Sunday's season opener against the Buffalo Bills, coach Rex Ryan said Friday.

Smith is dealing with hip and knee ailments. Defensive tackle Sione Po'uha, who has a back injury, is listed as questionable.

Ryan said he "feels better" about both players returning in Week 2.

"(Sione's) close. He really is close. He's begging us to play, but I think we're gonna be smart and give it a little time," Ryan said. "This is really the first week he's practiced. He was out there today, but we'll see."

It sounds like tight end Dustin Keller (hamstring) will play.

"(Dustin) looked good. I think he's ready to roll," Ryan said. "So we'll see how much it will limit him. I'm not sure, but he practiced today."

Defensive end Mike DeVito said his calf is 100 percent, so it sounds like the Jets will have him in the lineup as well.

Keller ran routes during the portion of Friday's practice open to the media. Po'uha and DeVito participated in position drills.

Second-year pro Kenrick Ellis will start in place of Po'uha. Yeremiah Bell and LaRon Landry will be the safeties.