Chandler, who has missed the past six games with a neck strain, did not participate in the Knicks' shootaround on Tuesday morning at TD Garden.
"If he tells me he's ready to go, then I'll play him," coach Mike Woodson said. "I don't know how many minutes, but we'll throw him in there and let him play, and he'll direct me as we go along."
While the Knicks have won four games in a row, they came against the Jazz, Magic and Raptors (twice) -- teams all under .500. Tuesday night's game marks the first contest of a challenging close to the season, during which the Knicks (42-26) only play four games against teams with losing records.
Chandler, a first-time All-Star and reigning Defensive Player of the Year, is averaging 10.7 points, 11 rebounds and 1.1 blocks per game.
If Chandler cannot go, Woodson said he will start the same five from the past three games: Pablo Prigioni, Raymond Felton, Iman Shumpert, Carmelo Anthony and Kenyon Martin, who has been averaging 16 points, seven rebounds and one block per game during that stretch.
On the Celtics' end, not only is their lead facilitator, Rajon Rondo, sidelined (right ACL tear), but also their best frontcourt defender, Kevin Garnett, was diagnosed with left ankle inflammation on Monday and could be out for the remainder of the regular season.