"I have not had my head in baseball for several days. Not since they called me from my house to tell me that my mom has cancer, "Colon told ESPNdeportes.com's Enrique Rojas at Turner Field after his pitching gem.
Colon first received word of his mother's health issue a day after his Mets debut, when he received the call from the Dominican Republic on Thursday.
His mother, Adriana Morales, had been diagnosed with breast cancer.
Morales, 63, will learn the result of further tests Wednesday.
"It's a situation where you're trying to be strong, but you cannot," Colon said. "Everyone in the family is very worried, hoping the results come out negative. But when you hear the word cancer, you always think the worst."
Colon said he plans to bring his mother to New York to ensure the best care.
"My mom is my best friend, my confidant," he said. "I talk to her every day, and the only thing that comforts me is that she has not lost her sense of humor. She is a very happy woman."