White needed 22 games. Smith has 18.5 sacks in his first 20 regular-season games.
Smith, who led the 49ers with 14 sacks as a rookie in 2011, had one sack wiped out by penalty in Week 4. He has 4.5 sacks through four games this season, putting him on pace for 18 sacks over a 16-game season.
Bills quarterback Ryan Fitzpatrick has taken only four sacks in 136 drop backs this season.
Additional Bills-49ers notes, from ESPN Stats & Information:
Fitzpatrick's 12 touchdown passes are a franchise record through four games.
Fitzpatrick has thrown all seven of his interceptions against teams sending four or fewer pass-rushers. The 49ers have picked off 21 passes since the beginning of last season when sending four or fewer, third-most in the NFL. Opposing defenses have sent five or more against Fitzpatrick on 35 of 136 drop backs. The 49ers have sent added pressure 20.7 percent of the time since the start of last season, the second-lowest rate in the NFL. That includes 27.1 percent this season.
Fitzpatrick completed only 2 of 10 passes when targeting Stevie Johnson in Week 4. Fitzpatrick and Johnson have the lowest completion percentage in the NFL this season among QB-WR combinations with at least 20 targets.
The 49ers have 386 yards rushing outside the tackles, most in the NFL by 83 yards. They average 7.9 yards per carry on these rushes, third-best in the league. Their 18 rushing first downs on these runs rank first in the league. The team gave left tackle Joe Staley a contract extension in 2009, after Staley's second season. Right tackle Anthony Davis, who appears to be playing at a high level, is already in his third season. Not that agents would ever think of such things.
Alex Smith's 29-yard pass to Vernon Davis in Week 1 stands as the 49ers' longest completion in 2012. San Francisco and Minnesota are the only teams without a 30-yard pass play. Smith had 15 such plays last season. The Bills have allowed three.
Aldon Smith has recorded 18 of his 18.5 sacks when the 49ers sent four or fewer pass-rushers. No player has more on such plays.