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San Francisco 49ers (2-4) at New York Giants (4-1), 1 p.m. ET
Trusting the Giants' Eli Manning is a lot easier than trusting the 49ers' J.T. O'Sullivan, even after Manning tossed three picks against the Browns in Week 6. That's where this game hinges.
Defenses are forcing O'Sullivan into interceptions at a furious rate. O'Sullivan has thrown seven picks in his last three games. The 49ers are 0-3 largely as a result.
The solution -- handing the ball to Frank Gore more frequently when the 49ers are leading -- appears almost too obvious. Look for that story line to get a rest this week. The Giants have the offensive line and playmaking ability to take the lead and force the 49ers into obvious passing situations. The combination should fuel a lopsided Giants victory.
Turnovers can be the great equalizer, something the Rams proved against the Redskins in Week 6. I just don't see the 49ers winning the turnover battle. The 49ers lead the NFL with 15 giveaways. The Giants rank third with only four.
Dallas Cowboys (4-2) at St. Louis Rams (1-4), 1 p.m. ET
The Rams are playing with an edge that helped them upset the Redskins while also nearly costing them the game. While they don't need any more 15-yard penalties from guard Richie Incognito, the new attitude players are showing under Jim Haslett does give them a chance to compete and possibly pull an upset.
It's probably wise to discount what the Rams had become under Scott Linehan. Their talent was better than that. The Rams thought their defensive line would provide a strong pass rush this season. I just question whether the Rams can score enough points to put the Cowboys in obvious passing situations.
This is a game Dallas should win even without Tony Romo. But the Cowboys can't take the outcome for granted. The Rams will beat teams that underestimate them.
Seattle Seahawks (1-4) at Tampa Bay Buccaneers (4-2), 8:15 p.m. ET
Seneca Wallace probably gets the start at quarterback for Seattle. A calf injury figures to limit his mobility, which was one of his strengths. I also question whether Wallace will be sharp enough after missing so much practice time in recent weeks.
The Seattle passing game simply isn't functioning at a high enough level for the Seahawks to beat good teams, particularly on the road. It's a stretch to think that will change dramatically with Wallace replacing Charlie Frye.
The Bucs think big-play receiver Joey Galloway has a chance to return from injury this week. That's fitting from a Seattle perspective. The Seahawks' defense is giving up big pass plays and Galloway -- traded by Seattle in 2000 -- figures to find openings deep downfield.