Most importantly, the Packers will be without starting left tackle Bryan Bulaga, who has suffered a torn ACL. This injury will force Green Bay to reconfigure a line that has been reconfigured quite a bit over the years. The 49ers' Justin Smith and Aldon Smith will face different matchups as a result. They combined for one sack in two games against the Packers last season. Marshall Newhouse, the Packers' starting left tackle in 2011 and 2012, could take over for Bulaga this season.
Meanwhile, the 49ers expect to have linebacker Patrick Willis back in plenty of time for the regular season after Willis underwent surgery to repair a fractured right hand. Willis has not practiced since suffering the injury during a collision with fullback Bruce Miller. He has played with a broken hand in the past. Willis is expected back within the next few weeks.