"Timetable? I don't have an idea on how long that's going to be," Pagano said.
Jones injured his ankle in the first quarter of the Aug. 29 preseason game against the St. Louis Rams. He missed seven games with a right ankle injury last season.
The Colts could place Jones on short-term injured reserve, which would allow him to begin practicing after six weeks and play in a game after eight weeks if they believe he can still play this season. The worst possible scenario for Jones would see him placed season-ending injured reserve.
Indianapolis signed Jones to a five-year, $33 million contract in 2014.