Rapid Reaction: Cardinals 41, Bills 17

Posted by ESPN.com's Tim Graham
The Buffalo Bills suffered two losses on Sunday, but their upcoming bye will help them cope.

The Bills couldn't reach their off week with an unblemished record, and their 41-17 loss to the Arizona Cardinals in University of Phoenix Stadium didn't have as much to do with Trent Edwards' injury as many might think.

It had more to do with the Bills' inability to handle a team that can throw.

Edwards left the game after three passes because of a concussion brought by a dizzying sack. The Bills couldn't recover, and although J.P. Losman had his moments, that precious bye week couldn't have come at a better time.

By all accounts, Edwards is the offensive leader. Losman, the man Edwards supplanted, hasn't exactly embraced a supporting role, but as Bills fans gulped hard while Edwards was being escorted off the field, having a serviceable backup had to provide a bit of relief. But not a huge sigh.

Losman completed 15 of 21 passes for 220 yards, much of it coming on an 87-yard touchdown hookup with Lee Evans. Losman also scampered for a touchdown. But he also threw an interception and lost a fumble.

The Bills never were in the game because their defense couldn't contain the first legitimate passing attack it faced. Not having top cornerback Terrence McGee (knee) certainly didn't help, but he couldn't have made a big enough difference had he played.

Even without Anquan Boldin, quarterback Kurt Warner threw for 250 yards and two TDs. He used nine different receivers to help the Cardinals hold the ball for 36:16. Of their 28 first downs, 17 of them were on pass plays.