JacksonLynchGaughan, citing an unnamed league source, states Jackson will be out four to six weeks with a broken left hand. Lynch will miss three to four weeks with a sprained ankle.
Three preseason games are left. The regular-season opener is four weeks away: Sept. 12 against the Miami Dolphins in Ralph Wilson Stadium.
Both backs were hurt on the opening drive of Friday night's lopsided preseason loss to the Washington Redskins.
Rookie running back C.J. Spiller will get that many more touches through the rest of the preseason. He was the ninth overall draft choice, but he doesn't provide the same substance as Jackson or Lynch.
Spiller, a dominant player in college, was hardly a workhorse at Clemson. He averaged only 15.4 carries a game his senior year.