Posted by ESPN.com's Tim Graham
That should pretty much do it.
The Buffalo Bills have a .500 record and are alone at the bottom of the AFC East with only four games to play.
So much for that scalding hot 4-0 start. The Bills also were 5-1 and the darlings of the AFC.
The Bills' defense, playing without safety Donte Whitner, cornerback Jabari Greer and Pro Bowl defensive end Aaron Schobel, performed well enough for a victory. The Bills gave up only 195 net yards (62 rushing, 133 passing) and just 12 first downs.
But the Bills' offense didn't show up, and kicker Rian Lindell missed two field goals.
Bills quarterback Trent Edwards was awful. J.P. Losman emerged from the bullpen at the start of the second half and mustered a semblance of offense, but not nearly enough. The Bills have stumbled against 3-4 defenses all season. Now they're 1-5 against them.
The 49ers, meanwhile, became the first team in 15 tries to travel three time zones eastward and win.