Readiness factor: The Bills will need every moment they can find to prepare for the season. Their offensive skill players gathered at quarterback Ryan Fitzpatrick's home in April. A larger contingent convened in Western New York for casual workouts in May.
Biggest challenge: Buffalo must find a defensive identity quickly. The Bills switched from a 4-3 defense to a 3-4 with bad results last year. As it became obvious they had the NFL's worst run defense, they mixed their fronts. Head coach Chan Gailey has said that they will be a hybrid defense leaning toward a 3-4 base. Then he hired longtime 4-3 mastermind Dave Wannstedt -- not to replace defensive coordinator George Edwards, but as assistant head coach and linebackers coach.
Line in the sand: The Bills have a tenuous offensive line, although all the late-season starters are back. The line mostly has been mediocre and often riddled with injuries. Demetrius Bell has been a bargain at left tackle, but far from dominant. Right guard Eric Wood could eventually shift to center.
Key players without contracts for 2011: Inside linebacker Paul Posluszny and safety Donte Whitner have been two of the Bills' most prolific tacklers. Cornerback Drayton Florence is an overlooked free agent who could be popular on the open market. Disappointing former first-round pick John McCargo is a goner.