Five nuggets of knowledge about Week 11:
Skelton's opportunity. Arizona Cardinals quarterback John Skelton steps up in class when he faces the San Francisco 49ers' defense. The matchup figures to be a tough one from a protection standpoint, but the Cardinals have found ways to strike for big plays this season. They have seven pass plays of at least 40 yards this season, fourth-most in the league behind Detroit, Green Bay and Houston. The 49ers have given up seven such plays, tied for fourth-most in the league. That gives Arizona a puncher's chance against the 49ers. And if Skelton can somehow pull out a victory, his stock will rise considerably.
Ganging up on power backs. Steven Jackson, Marshawn Lynch, Beanie Wells and Frank Gore give the NFC West four running backs able to dish out punishment. All are physical runners. I'm most interested in seeing whether Jackson can top 100 yards rushing for the fourth game in a row. He has 30 career games with at least 100 yards, but none against Seattle. That's surprising given that Jackson has faced the Seahawks more times than he has faced any other team -- 14, counting playoffs.
49ers hold their ground. Every NFL team but the 49ers has allowed at least three rushing touchdowns this season. San Francisco has allowed zero. The 49ers are the first team since the 1999 Jacksonville Jaguars to go nine games into a season without allowing one, according to ESPN Stats & Information. The Cardinals rank tied for 11th in the league with eight rushing scores, but they have zero in their past two games. Wells' injured knee has robbed power from him. Wells had only 10 carries for 29 yards against the 49ers last season. He did carry 15 times for 79 yards against them as a rookie in 2009.
Cornerbacks in focus. The St. Louis Rams and Seattle Seahawks will play without cornerbacks Ron Bartell, Bradley Fletcher, Jerome Murphy, Al Harris, Walter Thurmond or Marcus Trufant, among others. The team best able to exploit issues in the secondary could prevail. Seattle feels better about its cornerback situation, but the raw talent is questionable. Two of the Seahawks' five players at the position were undrafted. Two others are rookies. None of the five was drafted earlier than the fifth round. That was partly by design, however. The team traded 2006 first-rounder Kelly Jennings and 2007 second-rounder Josh Wilson.
Explosive potential in return game. Patrick Peterson and Ted Ginn Jr. give the Cardinals-49ers game big-play potential on returns. Peterson has helped Arizona go from 27th last season to second this season in punt-return average. He leads the NFL in that category with a 17.6-yard average among players with more than 15 punt returns. His three touchdowns on punt returns also lead the NFL. The 49ers' Ginn ranks third in punt-return average and third in kick-return average among players with more than 15 returns in each category. He also has two touchdowns. The Cardinals' kick returner, LaRod Stephens-Howling, has been quiet this season. He scored three times on returns over the previous two seasons.